Quick Answer: What Does High MCV Mean?

What is Macrocytic anemia caused by?

Megaloblastic anemia is caused by deficiency or impaired utilization of vitamin B12 and/or folate, whereas nonmegaloblastic macrocytic anemia is caused by various diseases such as myelodysplastic syndrome (MDS), liver dysfunction, alcoholism, hypothyroidism, certain drugs, and by less commonly inherited disorders of ….

What does MCV of 98 mean?

Mean corpuscular volume (MCV) measures the average red blood cell volume, meaning the actual size of the cells themselves. A normal range for MCV is between 80 and 96 femtoliters per cell.

What are the first signs of liver damage from alcohol?

Generally, symptoms of alcoholic liver disease include abdominal pain and tenderness, dry mouth and increased thirst, fatigue, jaundice (which is yellowing of the skin), loss of appetite, and nausea. Your skin may look abnormally dark or light. Your feet or hands may look red.

What are the symptoms of low MCV?

These symptoms include:Fatigue.Unusual bleeding or bruising.Cold hands and feet.Pale skin.

How long does it take for MCV to return to normal?

Stopping heavy drinking allows the bone marrow to recover, and the MCV usually returns to normal within two months.

What are signs that your liver is struggling?

SymptomsSkin and eyes that appear yellowish (jaundice)Abdominal pain and swelling.Swelling in the legs and ankles.Itchy skin.Dark urine color.Pale stool color.Chronic fatigue.Nausea or vomiting.More items…•

Is Macrocytic anemia serious?

Complications. Most cases of macrocytic anemia that are caused by vitamin B-12 and folate deficiencies can be treated and cured with diet and supplements. However, macrocytic anemias can cause long-term complications if left untreated. These complications can include permanent damage to your nervous system.

How high can MCV levels go?

High. In pernicious anemia (macrocytic), MCV can range up to 150 femtolitres. An elevated MCV is also associated with alcoholism (as are an elevated GGT and an AST/ALT ratio of 2:1). Vitamin B12 and/or folic acid deficiency has also been associated with macrocytic anemia (high MCV numbers).

What does it mean if your MCV is high?

The MCV is higher than normal when red blood cells are larger than normal. This is called macrocytic anemia. Macrocytic anemia can be caused by: Vitamin B-12 deficiency.

What does high MCV and MCH mean in a blood test?

What Do High MCH Levels Mean? Your MCH will reflect your MCV. That means you’ll have more hemoglobin if your red blood cells are larger than normal. Red blood cells can grow too large when you have fewer of them than normal — a condition called macrocytic anemia.

Does high MCV mean liver disease?

MCV values greater than 100 fl in patients with liver disease almost invariably indicate alcohol-related disease. In the short-term, changes in MCV are of little use in monitoring alcohol intake.

What causes changes in MCV?

Increased MCV can be associated with thyroid disease, folate deficiency, blood loss, pharmaceutical intake, nonalcoholic liver diseases, and various hematological disorders such as megaloblastic anemia.

Why is my MCH high?

High MCH scores are commonly a sign of macrocytic anemia. This condition occurs when the blood cells are too big, which can be a result of not having enough vitamin B12 or folic acid in the body. High MCH scores may also be the result of the following: liver diseases.

What causes high MPV?

Depending on your platelet count and other blood measurements, an increased MPV result can indicate: Thrombocytopenia, a condition in which your blood has a lower than normal number of platelets. Myeloproliferative disease, a type of blood cancer. Preeclampsia, a complication in pregnancy that causes high blood …

What medications cause high MCV?

Which drugs cause macrocytosis?Folate antagonists (eg, methotrexate )Purine antagonists (eg, 6-mercaptopurine [6-MP])Pyrimidine antagonists (eg, cytosine arabinoside [ara-C])Alkylating agents (eg, cyclophosphamide)Tyrosine kinase inhibitors (eg, sunitinib, and imatinib)Zidovudine (AZT)Trimethoprim.Oral contraceptive pills.More items…•

Why does MCV increase in alcoholism?

The mechanism of increased MCV is probably related to hematotoxicity of both alcohol and its metabolite, acetaldehyde. Alcohol can permeate the cell membrane and alter lipid structures of the membrane. In addition, alcohol can alter erythrocyte metabolism, thus altering its stability [8].

What are symptoms of high MCV?

If you have a high MCH value, you may experience the following symptoms:shortness of breath.chest pain.fast heartbeat.fatigue or weakness.very pale or yellowish skin.headache.

How can I improve my MCV?

To treat this, your doctor may recommend the following:Increase iron in your diet with foods like spinach.Take iron supplements.Get more vitamin B-6, which is necessary for proper absorption of iron.Add more fiber to your diet, which can help improve the intestinal absorption of iron.More items…•

What diseases cause large red blood cells?

Advertising & SponsorshipVitamin B-12 deficiency.Folate deficiency.Liver disease.Alcoholism.Hypothyroidism.A side effect of certain medications, such as those used to treat cancer, seizures and autoimmune disorders.Increased red blood cell production by the bone marrow to correct anemia, for example, after blood loss.More items…